These days, we don't have to worry too much about meeting an early demise from ulcers, breaks in the stomach lining that could be fatal back in the early 1900s. This is because we have medicines to treat them, like proton pump inhibitors! In this final episode of CrashCourseOrganicChemistry, we'll look at medicinalchemistry by breaking down how penicillin fights bacteria, how proteins are made both in the body and in the lab, and we'll finally finish the synthesis of penicillin V and complete the Mold Medicine Map! Hopefully this series has shown you the many ways organicchemistry is all around and how it can help to better understand ourselves, and improve the world!
Episode Sources: Patrick, G. L. (2013). An introduction to medicinalchemistry. Oxford university press. Vollmer, W., Blanot, D., & De Pedro, M. A. (2008). Peptidoglycan structure and architecture. FEMS microbiology reviews, 32(2), 149-167. Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J. W., ... & Charlier, P. (2007). Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Journal of molecular biology, 371(2), 528-539. PDB IDs (available at rcsb.org/): • 5CXW • 6TNA ( modified to show a bound amino acid)
Series Penicillin References: Nicolaou, K. C., & Sorensen, E. J. (1996). Classics in total synthesis: targets, strategies, methods. John Wiley & Sons. Sheehan, J. C. (1982). The enchanted ring: the untold story of penicillin. Primary literature for Sheehan’s penicillin synthesis: Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1948, 70, 1985: Sheehan, J.C. & Izzo, P.T. J. Am. Chem. Soc. 1949, 71, 4059: Sheehan, J.C. & Bose A.K. J. Am. Chem. Soc. 1950, 72, 5158: Sheehan, J.C., Buhle, E.L, Corey E.J., Laubach, G.D. & Ryan J.J. J. Am. Chem. Soc. 1950, 72, 3828: Sheehan, J.C. & Laubach, G.D. J. Am. Chem. Soc. 1951, 73, 4376: Sheehan, J.C. & Hoff, D.R. J. Am. Chem. Soc. 1957, 79, 237: Sheehan, J.C. & Corey E.J. J. Am. Chem. Soc. 1951, 73, 4756
Series Sources: Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry: 8th ed.: Cengage Learning, Boston, 2018. Bruice, P. Y., OrganicChemistry, 7th ed.: Pearson Education, Inc., United States, 2014. Clayden, J., Greeves, N., Warren., S., OrganicChemistry, 2nd ed.: Oxford University Press, New York, 2012. Jones Jr., M.: Fleming, S. A., OrganicChemistry, 5th ed.: W. W. Norton & Company, New York, 2014. Klein., D., Organic Chemistry: 1st ed.: John Wiley & Sons, United States, 2012. Louden M., Organic Chemistry: 5th ed.: Roberts and Company Publishers, Colorado, 2009. McMurry, J., OrganicChemistry, 9th ed.: Cengage Learning, Boston, 2016. Smith, J. G., Organic chemistry: 6th ed.: McGraw-Hill Education, New York, 2020. Wade., L. G., Organic Chemistry: 8th ed.: Pearson Education, Inc., United States, 2013.
*** Watch the videos and review your learning with the CrashCourse App! Download here for Apple Devices: apple.co/3d4eyZo Download here for Android Devices: bit.ly/2SrDulJ
CrashCourse is on Patreon! You can support directly by signing up at patreon.com/crashcourse
Thanks to the following patrons for their generous monthly contributions that help keep CrashCourse free for everyone forever: April Frazier, Dave Freeman, Hasan Jamal, DL Singfield, Lisa Owen, Jeremy Mysliwiec, Amelia Ryczek, Ken Davidian, Stephen Akuffo, Toni Miles, Steve Segreto, Michael M. Varughese, Kyle & Katherine Callahan, Laurel Stevens, Vincent, Michael Wang, Stacey Gillespie (Stacey J), Alexis B, Burt Humburg, Aziz Y, Shanta, DAVID MORTON HUDSON, Perry Joyce, Scott Harrison, Mark & Susan Billian, Junrong Eric Zhu, Rachel Creager, Breanna Bosso, Matt Curls, Tim Kwist, Jonathan Zbikowski, Jennifer Killen, Sarah & Nathan Catchings, team dorsey, Trevin Beattie, Divonne Holmes à Court, Eric Koslow, Jennifer Dineen, Indika Siriwardena, Khaled El Shalakany, Jason Rostoker, Shawn Arnold, Siobhán, Ken Penttinen, Nathan Taylor, Les Aker, ClareG, Rizwan Kassim, Sam Ferguson, Alex Hackman, Jirat, Katie Dean, Avi Yashchin, NileMatotle, Wai Jack Sin, Ian Dundore, Justin, Mark, Caleb Weeks __
Want to find CrashCourse elsewhere on the internet? Facebook - facebook.com/YouTubeCrashCourse Twitter - twitter.com/TheCrashCourse Instagram - instagram.com/thecrashcourse/