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December 24, 2021

Going out in the sun can work wonders for your mood, but unfortunately too much UV exposure can do serious damage to your DNA. This damage occurs through a type of organic reaction called a pericyclic reaction. In this episode of Crash Course Organic Chemistry, weโ€™ll explore pericyclic reactions to see how the sun can both give life, and hurt us, and also look at other important pericyclic reactions, such as the Diels-Alder reaction.

Episode Sources:
cen.acs.org/articles/95/i15/Remembering-organic-chemistry-legend-Robert-Burns-Woodward.html
nobelprize.org/prizes/chemistry/1950/alder/biographical/
nobelprize.org/prizes/chemistry/1981/summary/
nobelprize.org/prizes/chemistry/1981/fukui/facts/
uni-kiel.de/grosse-forscher/index.php?nid=diels&lang=e
Ohashi, M., Jamieson, C.S., Cai, Y. et al. An enzymatic Alder-ene reaction. Nature 586, 64โ€“69 (2020). doi.org/10.1038/s41586-020-2743-5

Further Reading on Pericyclic Reactions and the Woodward-Hoffman Rules:
chem.libretexts.org/Bookshelves/Organic_Chemistry/Supplemental_Modules_(Organic_Chemistry)/Reactions/Pericyclic_Reactions
Fleming, I. (1977). Frontier orbitals and organic chemical reactions. Wiley.

Series Sources:
Brown, W. H., Iverson, B. L., Ansyln, E. V., Foote, C., Organic Chemistry: 8th ed.: Cengage Learning, Boston, 2018.
Bruice, P. Y., Organic Chemistry, 7th ed.: Pearson Education, Inc., United States, 2014.
Clayden, J., Greeves, N., Warren., S., Organic Chemistry, 2nd ed.: Oxford University Press, New York, 2012.
Jones Jr., M.: Fleming, S. A., Organic Chemistry, 5th ed.: W. W. Norton & Company, New York, 2014.
Klein., D., Organic Chemistry: 1st ed.: John Wiley & Sons, United States, 2012.
Louden M., Organic Chemistry: 5th ed.: Roberts and Company Publishers, Colorado, 2009.
McMurry, J., Organic Chemistry, 9th ed.: Cengage Learning, Boston, 2016.
Smith, J. G., Organic chemistry: 6th ed.: McGraw-Hill Education, New York, 2020.
Wade., L. G., Organic Chemistry: 8th ed.: Pearson Education, Inc., United States,

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